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Alzheimer en kruiden

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Bij de ziekte van Alzheimer hebben we te maken met een globale achteruitgang van het functioneren van delen van de hersenen, die nodig zijn voor orientatie, geheugen en verwante vormen van gedrag. Ondersteuning, wandelen, goed dieet (vis) en ook kruiden kunnen ondersteunend werken. Kortgeleden werd een mooi overzichtsartikel over de waarde van kruiden bij Alzheimer gepubliceerd, waaruit blijkt dat Melissa officinalis (oertinctuur 3 maal daags 20 druppels) en Ginkgo een positieve bijdrage kunnen leveren bij het ondersteunen van geheugenproblemen.

Ook Salvia en enkele Chinese kruiden kunnen helpen bij symptomen van de ziekte van Alzheimer, en we geven hier de conclussie weer:[1]

The systematic review identified two herbs and herbal formulations with therapeutic effects for the treatment of AD:

  1. Melissa officinalis,
  2. Salvia officinalis,
  3. Yi-Gan San and BDW (Ba Wei Di Huang Wan),
  4. Ginkgo biloba.

All five herbs are useful for cognitive impairment of AD. M. officinalis and Yi-Gan San are also useful in agitation, for they have sedative effects.

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These herbs and formulations have demonstrated good therapeutic effectiveness but these results need to be compared with those of traditional drugs. Further large multicenter studies should be conducted in order to test the cost-effectiveness of these herbs for AD and the impact in the control of cognitive deterioration.

Literatuur

Akhondzadeh S, Noroozian M, Mohammadi M, Ohadinia S, Jamshidi AH. Salvia officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomized and placebo-controlled trial. J Clin Pharm Ther 2003;28:53–9. 

Akhondzadeh S, Noroozian M, Mohammadi M, Ohadinia S, Jamshidi AH, Khani M. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer’s disease: a double blind, randomized and placebocontrolled trial. J Neurol Neurosurg Psychiatr 2003;74:863–6.

Iwasaki K, Satoh-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N e cols. A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiatr 2005;66:248–52.

Iwasaki K, Kobayashi S, Chimura Y, Taguchi M, Inoue K, Cho S e cols. A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine ‘Ba Wei Huang Wan’ in the treatment of dementia. J Am Geriatr Soc 1994;52:1518–21.

Birks J, Grimley EJ. Ginkgo biloba for cognitive impairment and dementia. The Cochrane Library, Issue 2, 2004. Oxford: Update Software. 

Kennedy DO, Scholey AB, Tildesley NTJ, Perry EK, Wesnes KA. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953–64.

Kennedy DO, WakeBallard C, O’Brien J, Reichelt K, Perry E. Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double blind, placebo controlled trial. J Clin Psychiatr 2002;63:553–8. 

Cerny A, Schmid K. Tolerability and efficacy of valerian/lemon balm in healthy volunteers: a double-blind, placebo-controlled, multicenter study. Phytoterapia 1999;70:221–8.

Wong AHC, Smith M, Boon HS. Herbal remedies in psychiatric practice. Arch Gen Psychiatr 1998;55:1033–44. 24. Carnat AP, Carnat A, Fraisse D, Lamaison JL. The aromatic and polyphenolic composition of lemon balm (Melissa officinalis L. subsp. officinalis) tea. Pharm Acta Helv 1998;72:301–5.

Mulkens A, Stephanou E, Kapetenadis I. Heterosides a genines volatiles dans les feuilles de Melissa officinalis L. (lamiaceae). Pharm Acta Helv 1985;60:276–8.

Mantle D, Eddeb F, Pickering AT. Comparison of relative antioxidant activities of British medicinal plant species in vitro. J Ethnopharmacol 2000;72:47–51.

Hohmann J, Zupko I, Redei D, Csanyi M, Falkay G, Mathe I, et al. Protective effects of the aerial parts of Salvia officinalis, Melissa officinalis and Lavandula angustifolia and their constituents against enzyme-dependent and enzyme independent lipid peroxidation. Planta Med 1999;65:576–8.

Wake G, Court J, Pickering A, Lewis R, Wilkins R, Perry E. CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory. J Ethnopharmacol 2000;69:105–114.

Hirokawa S, Nose M, Amagaya S, Oyama T, Ogihara Y. Protective effect of hachimi-jio-gan, an oriental herbal medicinal mixture, against cerebral anoxia. J Ethnopharmacol 1993;40:201–6.

Hirokawa S, Nose M, Ishige A, Amagaya S, Oyama T, Ogihara Y. Effect of Hachimi-jio-gan on scopolamine-induced memory impairment and on acetylcholine content in rat brain. J Ethnopharmacol 1996;50:77–84.

Gagnier JJ, Boon H, Rochon P, Moher D, Barnes J, Bombardier C. CONSORT Group. Reporting randomized, controlled trials of herbal interventions: an elaborated CONSORT statement. Ann Intern Med 2006;144:364–7.

 

Referentie

[1] Leopoldo Luiz dos Santos-Neto et al. | The Use of Herbal Medicine in Alzheimer’ | http://www.iocob.nl/images/ziekten/artikel/alzheimer_kruiden_overzicht_2006.pdf | eCAM | 2006: 3(4)441-445.

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