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Boswellia, 5-LOXIN®, bij osteoartrose en reumapijn

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5–LOXIN is a phytocompound which improves joint pain, comfort and mobility. It also is claimed to help reducing the action of harmful enzymes that break down protective joint tissues. While a new ingredient, it is steeped in the historic roots of the Boswellia serrata plant, used in traditional Indian medicine for centuries. Thus, 5-LOXIN® is seen as a modern approach to tradition and history of Indian herbal therapy, being clinically proven for its effectiveness.

In a recent human study, both 100mg and 250mg of 5-LOXIN daily provided improvement in joint comfort and mobility within 7 days

 

  • 5-LOXIN provided significant benefits in WOMAC, VAS and LFI standardized testing methodologies for joint health
  • 5-LOXIN positively impacted biological markers associated with joint and general health, including TNFa, CRP, and IL-6
  • 5-LOXIN was shown to significantly inhibit matrix metalloproteinase (MMP-3), enzymes that break down cartilage, collagen and connective tissues
  • 5-LOXIN is well-tolerated, easy on the stomach and supported by extensive safety data [1] [2] [3]

 

Referentie

[1] Spitzner JR, Chung IK, Muller MT. | Eukaryotic topoisomerase II preferentially cleaves alternating purine-pyrimidine repeats. | Nucleic Acids Res. | 1990 Jan 11;18(1):1-11.

[2] Sengupta K, Alluri KV, Satish AR, Mishra S, Golakoti T, Sarma KV, Dey D, Raychaudhuri SP. | A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin for treatment of osteoarthritis of the knee. | Arthritis Res Ther. | 2008;10(4):R85. doi: 10.1186/ar2461. Epub 2008 Jul 30.

[3] Quan F, Forte MA. | Two forms of Drosophila melanogaster Gs alpha are produced by alternate splicing involving an unusual splice site. | Mol Cell Biol. | 1990 Mar;10(3):910-7.

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