Uit de grafieken valt af te lezen dat terwijl het homocysteine in het bloed duidelijk minder werd (grafiek rechts), de achteruitgang van de beide groepen op mentaal gebied (cognitie, gemeten met de ADAS score) even snel was (grafiek links). Hoe hoger de lijn gaat, hoe slechter het geheugen.

In de conclusie melden de onderzoekers dat het dus zinloos is om hoog gedoseerde vitamine B te geven aan patienten met Alzheimer:

This study was designed to determine if use of high-dose supplements to maximally reduce homocysteine levels in individuals with mild to moderate AD would slow the decline in cognition, clinical status, function, and behavior. The intervention was successful in reducing homocysteine levels but, in the study population as a whole, there was no evidence of benefit on any outcome measure. The general recommendation for B vitamin supplementation cannot be supported in patients with mild to moderate AD in the absence of B vitamin deficiency, at least in environments with folate enrichment of grains such as in the United States. 

High-Dose B Vitamin Supplementation and Cognitive Decline in Alzheimer Disease: A Randomized Controlled TrialPaul S. Aisen; Lon S. Schneider; Mary Sano; Ramon Diaz-Arrastia; Christopher H. van Dyck; Myron F. Weiner; Teodoro Bottiglieri; Shelia Jin; Karen T. Stokes; Ronald G. Thomas; Leon J. Thal; for the Alzheimer Disease Cooperative StudyJAMA. 2008;300(15):1774-1783. 

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