Andere middelen blijken aldus de Cochrane review zinvoller te zijn, zoals bijvoorbeeld cilostazol:

One study reported composite outcome on impairments (“physical sign score”) with decreasing score indicating improvement. In this study, the baseline mean was 7.10 (SD 0.40) in the 25 participants on IM vitamin B1 and B12 compared to 7.00 (SD 0.20) in the 25 participants on oral cilostazol, difference 0.1 (P = 0.27). After four weeks of treatment, the means were 6.90 (SD 0.30) and 6.40 (SD 0.30), respectively, with statistically significant difference favouring cilostazol (MD 1.64, 95% CI 0.99 to 2.29) (Hu, 2004).  

Ook bleek alfa-liponzuur dus zinvoller dan vitamine B:

Ziegler 1993 reported a significant reduction in paraesthesiae in the lower extremity in the group treated with alpha-lipoic acid compared to the group on vitamin B1 after 15 weeks of treatment (P < 0.05) but did not give any more details.  

Ook een andere studie toonde superioriteit aan van alfa-liponzuur.

De zogenaamde klare taal samenvatting van de Cochrtane groep was:

Peripheral neuropathy is a disorder of the peripheral nerves resulting from different causes, such as diabetes mellitus and alcoholism, leading to pain, numbness or weakness of the limbs and other problems.

Vitamin B is commonly used to treat peripheral neuropathy but it is not clear if it helps. This review of 13 trials on diabetic and alcoholic peripheral neuropathy with a total of 741 participants showed only one study that suggested possible short-term benefit from eight-week treatment with benfotiamine (a derivative of vitamin B1) with slightly greater improvement in vibration perception threshold compared to placebo.

Vitamin B complex when given in a higher dose administered for four weeks was more efficacious than a lower dose in reducing pain and other clinical problems based on another study.

Two to eight weeks of treatment with vitamin B was less efficacious than alpha-lipoic acid, cilostazol or cytidine triphosphate in short-term improvement of clinical and nerve test findings.  ^[1]

Bronnen:

Ang CD, Alviar MJM, Dans AL, Bautista-Velez GGP, Villaruz-Sulit MVC, Tan JJ, Co HU, Bautista MRM, Roxas AA. Vitamin B for treating peripheral neuropathy. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.: CD004573. DOI: 10.1002/14651858.CD004573.pub3.  

Hu JF, Su Q, Xing HL. Effect of cilostazol on peripheral conductive velocity and syndrome of limb pain and numbness in patients with diabetes. Zhongguo Linchuang Kang fu [Chinese Journal of Clinical Rehabilitation] 2004;8(18):3523–5. 

Kovrazhkina EA, Ayriyan NY, Serkin GV, Glushkov KS, Pavlov NA, Gekht AB, et al.Possibilities and perspective of berlition usage in the treatment of alcohol polyneuropathy. Journal of Neurolog y and Psychiatry 2004;104(2):33–7. Woelk 1998 {published data only}  

Ziegler D, Mayer P, Muhlen H, Gries FA. Effects of alpha-lipoic acid and vitamin B1 treatment on diabetic neuropathy [Effekte einer ther- apie mit alpha–liponsaure gegenuber vitamin B1 bei der diabetischen neuropathie]. Diabetologie und Stoffwechsel 1993;2:443–8. 

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